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→Description of problem
Disease causing mutations are often shared by a very small number of people due to evolutionary pressure. For genes involved in drug transport and metabolization, the evolutionary pressure is much weaker, and therefore the variants may be common.
An additional difficulty with determining genetic effect is for larger structural variants caused by copy number variations, pseudogenes or repeated regions. A good example of this is CYP2D6.
[[File:cyp2d6_outline.png|thumb|The effect of variants is also influenced by pseudogenes and repeated regions, as shown here for CYP2D6]]
===Computational methods===
