Anonymous

Changes

PGx in Estonia

35 bytes added, 14:37, 24 August 2018
Challenges and solutions
! [[NGS|Challenge]] !! Solution !! Comments
|-
| [[Allele definition]] || Pruning of allele definitions (removing variants from allele definitions (i.e. only keeping variants that destroys the protein), removing [[Unknown function|alleles with unknown function]]) || The allele pruning also makes it more likely that patients are indeed have normalphenotype (instead of unknown phenotype), removing most sources to [[Unknown function|alleles with unknown function]]
|-
| [[NGS|HLA-typing]] || [https://www.ncbi.nlm.nih.gov/pubmed/23762245 SNP2HLA] tool (WGS only) || A review of HLA-typing methods [https://www.ncbi.nlm.nih.gov/pubmed/27802932 from Bauer ''et al.''] does not mention this tool