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Pharmacoracle

6 bytes removed, 13:10, 27 February 2019
Hints on how to use Pharmacoracle (version 1)
===Hints on how to use Pharmacoracle (version 1)===
In order to write queries to an OWL ontology we need to know the names of the OWL elements, notably OWL Properties (e.g. has_haplotype) and and OWL Classes (e.g. TPMTstar3A). <ref>The Oslo University Hospital PGx OWL ontology that is used by the Pharmacoracle is still work in progress, but it is possible to have a closer, off-line look at the latest OWL version of the [https://www.pgx.no/farmakorakel/haplotypes.owl GRCh37 star allele definitions], which is best studied in [https://protegewiki.stanford.edu/wiki/Protege4UserDocs Stanford's Desktop Protégé]. For an introduction to PGx OWL ontology curation, have a look at our tutorial for [[WebProtege]]</ref>.
In addition we need to know the Manchester expressions of cardinality that are used to connect OWL Properties and OWL Classes, in particular:
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In order to query the Pharmacoracle automatically, we have made a Python script [[Pharmacolyzer]] that returns dosing recommendation based on a [[Pharmacotyper|pharmacotyped]] patient VCF.
===Examples of use===