==Alleles with unknown biochemical consequencefunction==''Unknown funtion'' means that the biochemical function of the allele is unknown or uncertain.There are at least three four kind of alleles that have unknown biochemical function*Known PGx alleles that are classified with unknown functional ''Unknown function'' status by PharmGKB*Alleles PGx alleles that are listed by PharmGKB, but has no functional status* Unknown alleles with variants that cause changes to the protein, but which are not classified by PharmGKB*Alleles Unknown alleles with variants that do not cause changes to the protein, and which are not classified by PharmGKB
There is no explicit dosing recommendation for patients with an unknown biochemical function allele on at least one chromatid. This means that there is no special medication recommendation '''even if the sister-chromatid has ''No function'' or ''Increased function'''''.
This dosing recommendation is very conservative, and the question is whether the allele with ''Unknown function'' should rather be treated as a ''Normal function'' allele (thereby assigning modified dosing recommendations to e.g. ''Unknown function''/''No function''-patients).
In ==Alleles with normal biochemical function==Normal function means that the CPIC guidelines, some PGx alleles have unknown biochemical functional status. The dosing recommendation for such patients function of the allele is sufficiently close to follow the average that a normal medication advicerecommendation can be used. There Alleles with normal biochemical function are * PGx-alleles that are classified with biochemical ''Normal function'' status by PharmGKB* alleles with no variants (these "wildtype" alleles are usually explicitly classified as ''Normal function'' by PharmGKB, and otherwisebut not always)In addition, all patients without a known PGxat least in the world of SNP-allele match also arrays, the definition of ''Normal function'' alleles and ''Unknown function'' alleles are overlapping* Alleles that are '''not''' classified (by PharmGKB) have unknown ''Normal function.''
==Alleles In other words: the definitions ''Normal function'' and ''Unknown function'' are overlapping. If we replace the ''Unknown function'' classification with normal bio-chemical consequence==The bio-chemical ''Normal function varies '', dosing recommendations for all these patients, and [[Normal function]] just means that the functional status is sufficiently close have to the mean that the normal medication recommendation can be usedchanged accordingly.There are at least two kind of alleles that have normal