==Alleles with unknown biochemical consequencefunction==''Unknown funtion'' means that the biochemical function of the allele is unknown or uncertain.There are at least three four kind of alleles that have unknown biochemical function*Known PGx alleles that are classified with ''Unknown function'' status by PharmGKB*Alleles PGx alleles that are listed by PharmGKB, but has no functional status* Unknown alleles with variants that cause changes to the protein, but which are not classified by PharmGKB*Alleles Unknown alleles with variants that do not cause changes to the protein, and which are not classified by PharmGKB

The There is no explicit dosing recommendation for patients with ''Unknown functional status'' is to follow the normal medication advicean unknown biochemical function allele on at least one chromatid. This means that*If the patient has an allele with unknown function, the recommended action there is to follow normal dosing regime, no special medication recommendation '''even if the other allele sister-chromatid has ''No function'' or ''Increased function'''''.

This dosing recommendation is very conservative, and the question is whether the allele with ''Unknown function'' should rather be treated as a ''Normal function'' allele (thereby assigning modified dosing recommendations to e.g. ''Unknown function''/''No function''-patients). ==Alleles with normal bio-chemical consequencebiochemical function==The bio-chemical function varies for all patients, and [[Normal function]] just means that the functional status biochemical function of the allele is sufficiently close to the mean average that the a normal medication recommendation can be used.There Alleles with normal biochemical function are * PGx alleles that are classified with ''Normal function'' status by PharmGKB* alleles with no variants (these "wildtype" alleles are usually explicitly classified as ''Normal function'' by PharmGKB, but not always)In addition, at least two normalin the world of SNP-arrays, the definition of ''Normal function'' alleles and ''Unknown function'' alleles are overlapping* Alleles that are '''not''' classified (by PharmGKB) have ''Normal function'' In other words: the definitions ''Normal function'' and ''Unknown function'' are overlapping. If we replace the ''Unknown function'' classification with ''Normal function'', dosing recommendations for these patients have to be changed accordingly.