Changes

There are at least three four kind of alleles that have unknown biochemical function

* Alleles PGx alleles that are listed by PharmGKB, but has no functional status* Unknown alleles with variants that cause changes to the protein, but which are not classified by PharmGKB* Alleles Unknown alleles with variants that do not cause changes to the protein, and which are not classified by PharmGKB

The There is no explicit dosing recommendation for patients with an unknown biochemical function allele on at least one chromatid, is to follow the normal medication advice. This means that normal there is no special medication is recommended, recommendation '''even if the sister-chromatid has ''No function'' or ''Increased function'''''.

This dosing recommendation is very conservative, and the question is whether the allele with ''Unknown function'' should rather be treated as a ''Normal function'' allele(thereby assigning modified dosing recommendations to e.g. ''Unknown function''/''No function''-patients).

[[Normal function]] means that the biochemical function of the allele is sufficiently close to the average that a normal medication recommendation can be used.

* alleles with no variants (which these "wildtype" alleles are usually explicitly classified as ''Normal function'' by PharmGKB, but not always)

* Alleles that are '''not''' classified (by PharmGKB ) have ''Normal function''

If we replace the ''Unknown function'' classification with ''Normal function'', dosing recommendations will for these patients have to be changed accordingly.