The There is no explicit dosing recommendation for patients with an unknown biochemical function allele on at least one chromatid, is to follow the normal medication advice. This means that normal there is no special medication is recommended, recommendation '''even if the sister-chromatid has ''No function'' or ''Increased function'''''.

This dosing recommendation is very conservative, and the question is whether the allele with ''Unknown function'' should rather be treated as a ''Normal function'' allele (thereby assigning special modified dosing recommendations to e.g. ''Unknown function''/''No function''-patients).

[[Normal function]] means that the biochemical function of the allele is sufficiently close to the average that a normal medication recommendation can be used.

* alleles with no variants (which these "wildtype" alleles are usually contained in the PGx alleles that are explicitly classified as ''Normal function'' by PharmGKB, but not always)

* Alleles that are '''not''' classified (by PharmGKB ) have ''Normal function''