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→Alleles with normal biochemical function
==Alleles with normal biochemical function==
Alleles with normal biochemical function are
* PGx alleles that are classified with ''Normal function'' status by PharmGKB
* alleles with no variants (these "wildtype" alleles are usually explicitly classified as ''Normal function'' by PharmGKB, but not always)
In addition, at least in the world of SNP-arrays, the definition of ''Normal function'' alleles and ''Unknown function'' alleles are overlapping
* Alleles that are '''not''' classified (by PharmGKB ) have ''Normal function''
In other words: the definitions ''Normal function'' and ''Unknown function'' are overlapping.
If we replace the ''Unknown function'' classification with ''Normal function'', dosing recommendations for these patients have to be changed accordingly.