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Unknown function

115 bytes added, 10:35, 6 August 2018
Alleles with unknown biochemical function
* Unknown alleles with variants that do not cause changes to the protein, and which are not classified by PharmGKB
The dosing recommendation for patients with an unknown biochemical function allele on at least one chromatid, is to follow the normal medication advice. This means that normal medication is recommended, '''even if the sister-chromatid has ''No function'' or ''Increased function'''''.
This dosing recommendation is very conservative, and the question is whether the allele with ''Unknown function'' should rather be treated as a ''Normal function'' allele(thereby allowing special dosing recommendations for e.g. ''Unknown function''/''No function''-patients).
==Alleles with normal biochemical function==