There are at least three kind of alleles that have unknown-biochemical function*Known PGx alleles that are classified with unknown functional status by PharmGKB*Alleles with variants that cause changes to the protein*Alleles with variants that do not cause changes to the protein In the CPIC guidelines, some PGx alleles have unknown bio-chemical functional status. The dosing recommendation for such patient patients is to follow the normal medication advice. There are PGx-alleles that are classified with bio-chemical function, and otherwise, all patients without a known PGx-allele match also have unknown function. ==Alleles with normal bio-chemical consequence==The bio-chemical function varies for all patients, and [[Normal function]] just means that the functional status is sufficiently close to the mean that the normal medication recommendation can be used.