Changes

==Alleles with unknown biochemical consequencefunction==''Unknown funtion'' means that the biochemical function of the allele is unknown or uncertain.

*Known PGx alleles that are classified with ''Unknown function'' status by PharmGKB*Alleles with variants that cause changes to the protein, but which are not classified by PharmGKB*Alleles with variants that do not cause changes to the protein, and which are not classified by PharmGKB

The dosing recommendation for patients with ''Unknown functional status'' unknown biochemical function on at least one chromatid is to follow the normal medication advice. This means that*If the patient has an allele with unknown function, the normal medication is recommended action is to follow normal dosing regime, '''even if the other allele sister-chromatid has ''No function'' or ''Increased function'''''.

This dosing recommendation is very conservative, and the question is whether the allele with ''Unknown function'' should rather be treated as a ''Normal function'' allele. ==Alleles with normal bio-chemical consequencebiochemical function==The bio-chemical function varies for all patients, and [[Normal function]] just means that the functional status biochemical function of the allele is sufficiently close to the mean average that the a normal medication recommendation can be used.There are at least two three kind of alleles that have normalbiochemical function* PGx alleles that are classified with ''Normal function'' status by PharmGKB* Any allele that is '''not''' classified by PharmGKB* An allele with no variants In other words: the definitions ''Normal function'' and ''Unknown function'' are partially overlapping.