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WebProtege

1,138 bytes added, 13:01, 20 September 2018
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[[File:WebProtege choose view and arrow lowres.png|frameless|Add a view by clicking the three horizontal bars, and chose appropriate view that will appear as a box that can be placed as desired]]
 
==Using WebProtégé for curation of PGx recommendations==
We suppose that the user has modified the ''Classes'' tab as explained above. We will use the drug voriconazole as an example.
By navigating in the ''Class Hierachy'' view, the curator can e.g. view the class element ''Voriconazole CYP2C19:Decreased function''. The naming is based on the functional status that is provided by PharmGKB's API, and the drug and gene name is added because functional status is gene specific and possibly drug specific (may be sensible to make functional status independent of drug, cf. Voriconazole Phenotype below). In the definition of the ''Voriconazole CYP2C19:Decreased function'', pay attention to the ''OWL Entity Description Editor'' where we see that the ''Voriconazole CYP2C19:Decreased function'' is equivalent to a gene that has haplotype either CYP2C19*10, CYP2C19*16, CYP2C19*19, CYP2C19*25, CYP2C19*26 or CYP2C19*9:
 
[[File:WebProtege user interface func status.png|frameless|Inspection of the element ''Voriconazole CYP2C19: Decreased function'' from the Class Hierarchy describing PGx recommendations for the drug Voriconazole]]